Metal nanoparticles have been tremendously utilised as antibacterial and anticancer agents. Although metal nanoparticles exhibit biocidal activity, but the drawback of toxicity on normal cells limits their clinical applications. Therefore, improving the bioactivity and minimizing the toxicity of the nanomaterials is paramount for biomedical applications. However, the design of nanomaterials with divalent ions and biomolecules (i.e. biomolecule curcumin, biopolymers) can improve the biosafety of the metal nanoparticles. In addition, the biogenic process can minimise the toxicity of innovative nanomaterials. This presentation addresses the importance of nanotoxicity nanomaterials, their development, and their applicability in clinical and 3-D printing applications. Additionally, our recent studies on biomolecule curcumin, biopolymer chitosan, and alginate influence on various metal nanomaterials and their mechanism are also discussed. Overall, how this nanomaterials will be useful for next generation of applications will be discussed.
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