Perhaps the newest research topics on high-performance lab-on-chip and detection at the lowest scale level are nanofluidics. A rapid and growing interest in this exciting area has led to the creation of new research methods for the study of the most complex structures in biology, chemistry, and nanotechnology.

Usually, nanofluidics is characterized as the study of fluid motion through tiny structures with dimensions between 1 and 100 nm in size. The first milestones that researchers can implement in a small-scale investigation are micro and nano manipulations. In contrast with classical macroscale assumptions, atomistic properties or mass transport take on another sense at a small volume.

New fields such as single-cell omics would involve the creation of new developments in nanofluidic instruments, biology, and medicine. The ability to facilitate large single-cell manipulation studies with studies at the level of organelles is a priority. Simple and complex nanochannels need to be studied before that, and it is necessary for technologies such as low-cost nanolithography and non-lithography to achieve the best shape needed in the future to expand the commercial products and applications of solid-state nanofluidic devices.

Eventually, the developments in nanofluidics will develop the processes of chemical synthesis and the manufacture of materials in a way that the studies in the liquid phase will take into account the above-mentioned technologies.